Video: Basal Ganglia Overview, Direct & Indirect Pathways
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Timestamps
00:15 Symptoms of Huntington’s disease – hyperkinetic chorea then akinesia
00:50 Genetics of HD
2:36 Genetic anticipation – when a disease gets worse/amplified due to more mutations accumulating throughout generations
3:23 Recap of direct and indirect pathways
3:58 Effect of dopamine on direct and indirect pathways
4:32 Pathophysiology 1: Excessive dopamine leading to hyperkinesia – treat with tetrabenzine
5:20 Pathophysiology 2: Degeneration of Indirect (ENK) pathway
6:15 Pathophysiology 3: Degeneration of direct and indirect pathway 🙁
6:43 Huntingtons brain scans