Paraneoplastic Syndrome:

Cachexia:

Hormone Based therapy
• Protein Kinases inhibitors
• Monoclonal antibodies
• antineoplastic drugs
• cell based therapies

Goldie-Coldman hypothesis:
o the probability of a resistance cell occurring = number of cells x
mutation rate

• Combining drugs works better if:
o there is a significant therapeutic benefit compared to monotherapy
o doesn’t result in unacceptable toxicity