Notes: Y2 GDC Pharm - antivirals
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• Viral Life Cycle:
1. attachment and entry
2. viral nucleic acid replication
3. production and processing of viral proteins and coat assembly of virions
4. viral release and shedding
• Targets:
1. attachment
2. reverse transcriptase
3. viral protease
4. viral DNA polymerase
5. protein translation and assembly of virus
6. inhibit viral shedding
• Nucleoside Reverse Transcriptase Inhibitors:
1. zidovudine, zalcitidine, didanosine, lamivudine
• Nucleotide Reverse Transcriptase Inhibitors:
1. tenofovir, adefovir, lamivudine
• Non-nucleoside reverse transcriptase inhibitors (NNRTIs):
1. nevirapine, efavirenz, delavirdine
• Inhibition of viral integrase:
1. elvitegravir, raltegravir
• Inhibition of viral proteases:
1. saquinavir, ritonavir, indinavir
• Highly active anti-retroviral therapy (HAART):
1. nucleoside RT inhibitor, NNRTIs, protease inhibitor
• Inhibition of viral polymerases
1. (herpes simplex, VZV, cytomegalovirus, adenvirus, papilloomavirus)
• Nucleoside analogues for HSV, VZV:
1. idoxuridine, vidarabine
• DNA Polymerase inhibitors:
1. aciclovir, valaciclovir, penciclovir, famciclovir, ganciclovir, foscarnet
• Inhibition of protein translation and assembly of the virus:
1. interferons
• Inhibition of viral shedding:
1. oseltamivir, zanamivir
