Y2 Pharm Notes: Congestive Heart Failure

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🖋️ Notes: Y2 pharm - Congestive heart failure

Similar resources:

Y2heartpharm, CHF, vasodilators

anti-thrombotic- warfarin (anticoagulant), aspirin (antiplatelet)
o statin- only help patients with hypercholesterolaemia or ischaemic heart
disease
o non-dihydropyridine calcium channel blocker- (verapamil) harmful due
to negative inotropic action
o NSAIDs- (ibuprofen)- promotes water and salt retention (harmful)

Beta-Blockers: bisoprolol, carvedilol, ramipiril, captopril, losartan , nitrates, spironolactone , sacubitril

ACE inhibitors:

Angiotensin Receptor blockers:

Vasodilators:

Mineralocorticoid receptor antagonists:

Sacubitril Valsartan:

DIURETICS

Digoxin:

Angiotensin-Converting Enzyme (ACE) Inhibitors

Commonly prescribed include:

  • Captopril (Capoten)
  • Enalapril (Vasotec)
  • Fosinopril (Monopril)
  • Lisinopril (Prinivil, Zestril)
  • Perindopril (Aceon)
  • Quinapril (Accupril)
  • Ramipril (Altace)
  • Trandolapril (Mavik)

Angiotensin II Receptor Blockers (or Inhibitors)

(Also known as ARBs or Angiotensin-2 Receptor Antagonists)

Commonly prescribed include:

  • Candesartan (Atacand)
  • Losartan (Cozaar)
  • Valsartan (Diovan)

Angiotensin-Receptor Neprilysin Inhibitors (ARNIs)

ARNIs are a new drug combination of a neprilysin inhibitor and an ARB.

  • Sacubitril/valsartan

If Channel Blocker (or inhibitor)

This drug class reduces the heart rate, similar to another class of drugs called beta blockers.

  • Ivabradine (Corlanor)

Beta Blockers (Also known as Beta-Adrenergic Blocking Agents)

Commonly prescribed include:

  • Bisoprolol (Zebeta)
  • Metoprolol succinate (Toprol XL)
  • Carvedilol (Coreg)
  • Carvedilol CR (Coreg CR) Toprol XL

Aldosterone Antagonists

Commonly prescribed include:

  • Spironolactone (Aldactone)
  • Eplerenone (Inspra)

Hydralazine and isosorbide dinitrate (specifically benefits African-Americans with heart failure)

Commonly prescribed:

  • Hydralazine and isosorbide dinitrate (combination drug) – (Bidil)

Diuretics (Also known as water pills)

Commonly prescribed include:

  • Furosemide (Lasix)
  • Bumetanide (Bumex)
  • Torsemide (Demadex)
  • Chlorothiazide (Diuril)
  • Amiloride (Midamor Chlorthalidone (Hygroton)
  • Hydrochlorothiazide or HCTZ (Esidrix, Hydrodiuril)
  • Indapamide (Lozol)
  • Metolazone (Zaroxolyn)
  • Triamterene (Dyrenium)
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